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http://www.cmaj.ca/content/early/2011/09/06/cmaj.110454

A recent study (link above) in the Canadian Medical Association Journal found an increased risk of spontaneous miscarriage in women who took NSAIDs (Ibuprofen, Motrin, Naproxen, Diclofenac, among others) in their first 20 weeks of pregnancy.  This review compared 4,700 women with miscarriage with 47,000 women that did not miscarry, and found that those that took an NSAID in their first 20 weeks of pregnancy had twice the rate of miscarriage. 

It has long been known that these medications should not be used late in pregnancy, but this study inreases the concern for their use earlier as well. 

KEY TAKE-AWAY:Pregnant women should avoid taking these medications without an indepth discussion with their doctor and consider taking Tylenol (Acetaminophen) for pain or fever during pregnancy.

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